The AMC3301 is a fully differential, precision, isolated amplifier with a fully integrated DC/DC converter that can supply the device from a single 3.3-V or 5-V voltage supply on the low-side. The input stage of the device consists of a fully differential amplifier that drives a second-order, delta-sigma (ΔΣ) modulator. The modulator uses an internal voltage reference and clock generator to convert the analog input signal to a digital bitstream. The drivers (termed TX in the Functional Block Diagram) transfer the output of the modulator across the isolation barrier that separates the high-side and low-side voltage domains. As shown in the Functional Block Diagram, the received bitstream and clock are synchronized and processed by a fourth-order analog filter on the low-side and presented as a differential output of the device

The signal path is isolated by a double capacitive silicon dioxide (SiO₂) insuation barrier, whereas power isolation uses an on-chip transformer separated by a thin-film polymer as the insulating material.